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Abstract #0678

Susceptibility artifact correction in MR thermometry during microwave ablation of liver lesions

Mingming Wu1,2, Christof Boehm1, Osman Oecal2, Matthias Fabritius2, Pierre Bour3, Thibaut Faller3, Eber Dantas4, Valéry Ozenne4, Jens Ricke2, Dimitrios Karampinos1, Olaf Dietrich2, and Max Seidensticker2
1Institute for Diagnostic and Interventional Radiology, Technical University of Munich, Munich, Germany, 2Department of Radiology, Ludwig Maximilian University of Munich, Munich, Germany, 3Certis Therapeutics, Pessac, France, 4UMR5536/CRMSB, Université de Bordeaux CNRS, Bordeaux, France

Synopsis

Keywords: Thermometry/Thermotherapy, Liver

Motivation: Safe and efficient thermoablation of liver lesions requires accurate real-time MR-thermometry as feedback for the operator.

Goal(s): Improved relative MR-thermometry based on proton resonance frequency shift by correcting artifacts originating from susceptibility changes applied in real-time respiratory-triggered EPI during microwave ablation of the liver.

Approach: Solving the Laplacian boundary value (LBV) problem as well as the total field inversion (TFI) method to phase difference maps before extracting the temperature change maps. In-vivo microwave ablation sessions in 5 patients have been retrospectively corrected.

Results: In all 5 patients, LBV robustly removed susceptibility artifacts in proximity of the heated area, while TFI tended to overfit.

Impact: Susceptibility artifact correction improves real-time MR thermometry guidance of thermoablation therapies of patients with liver lesions. More accurate temperature maps will provide increased safety during the ablation and improve efficiency by ensuring sufficient thermal dose delivery to the target tissue.

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