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Abstract #0680

MRI-Guided Trans-Perineal Cryoablation in the Treatment of Primary Prostate Cancer: A Prospective Study

Setayesh Sotoudehnia 1, Lance Mynderse2, Scott Thompson1, Aiming Lu1, Ali Ganjizadeh 1, Angela Bathke1, Daniel Adamo1, and David Woodrum1
1Interventional Radiology, Mayo Clinic, Rochester, MN, United States, 2Urology, Mayo Clinic, Rochester, MN, United States

Synopsis

Keywords: MR-Guided Interventions, Prostate, Cancer

Motivation: Prostate cancer is a leading cause of cancer in men, with limited minimally invasive focal treatments available. This study explores MRI-guided cryoablation as a precise alternative to traditional therapies.

Goal(s): To evaluate the efficacy and safety of MRI-guided trans-perineal cryoablation in reducing PSA levels and recurrence rates while managing adverse effects in prostate cancer patients.

Approach: In a prospective study, 100 patients received MRI-guided cryoablation with four cryoneedles and freeze/thaw cycles, followed by PSA, MRI, and biopsy monitoring.

Results: One-year follow-up showed up to 60% PSA reduction, an 11.1% recurrence rate, and manageable urinary and erectile side effects.

Impact: MRI-guided trans-perineal cryoablation shows promise as a minimally invasive, precise treatment for localized prostate cancer, with significant PSA reductions and a low 11.1% recurrence rate. These findings support its potential as an effective alternative to traditional therapies.

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