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Abstract #0683

Impact of subconcussive head acceleration on brain microstructure: Longitudinal diffusion MRI findings and symptom correlation

Christian John Alivio Saludar1, Maryam Tayebi1,2, Eryn Kwon1,2,3, Joshua McGeown2,3, Tuterangi Nepe-Apatu2, Paul Condron2,3, Leigh Potter2, Samantha Holdsworth2,3, Mātai mTBI Research Group2, Justin Fernandez1,2, Miriam Scadeng2,3, Alan Wang1,2,3, and Vickie Shim1,2
1Auckland Bioengineering Institute,University of Auckland, Auckland City, New Zealand, 2Mātai Medical Research Institute, Gisborne, New Zealand, 3Faculty of Medical and Health Sciences & Centre for Brain Research, University of Auckland, Auckland City, New Zealand

Synopsis

Keywords: Traumatic Brain Injury, Traumatic brain injury

Motivation: Subconcussive head acceleration is correlated with brain microstructural changes accompanied with long-term cognitive sequelae which pose serious health concerns.

Goal(s): To determine if subconcussive head acceleration affects the brain microstructure of contact sports athlete and evaluate if it is correlated with clinical symptom scores.

Approach: Diffusion MRI was used to study white matter changes over a season of rugby in athletes, relative to controls and own baseline.

Results: Increased cluster size of significant difference identified in contact sport athletes compared with non-contact sport controls suggest axonal damage and is correlated with symptom count and severity even without concussion diagnosis.

Impact: Findings raise importance of integrating neuroimaging in clinical tests of subconcussive head acceleration to determine extent of alteration, design removal from play to allow brain microstructure recovery, and prevent long-term neurologic effects, neuropsychological sequelae, and possible disability.

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