Abstract #0686

Effect of Low-Level Light Therapy on brain metabolite in Patients with Moderate Traumatic Brain Injury

Eva-Maria Ratai^1,2, Michael Wenke¹, Nathaniel Mercaldo¹, Suk-Tak Chan^1,2, Maria G. Figueiro-Longo¹, Jonathan Welt³, Arman Avesta¹, Jarone Lee⁴, Michael Lev¹, Blair Parry⁴, Lynn H Drake⁵, Richard H Anderson⁵, Terry Rauch⁶, Ramon Diaz-Arrastia⁷, Michael Hamblin⁵, Benjamin Vakoc⁵, and Rajiv Gupta¹

¹Radiology, Massachusetts General Hospital, Boston, MA, United States, ²Athinoula A. Martinos Center for Biomedical Imaging, Charlestown, MA, United States, ³Radiology, University of California, Irvine, CA, United States, ⁴Emergency Medicine, Massachusetts General Hospital, Boston, MA, United States, ⁵Wellman Center for Photomedicine, Massachusetts General Hospital, Boston, MA, United States, ⁶Office of Secretary of Defense, Washington, DC, United States, ⁷Neurology, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Traumatic Brain Injury, Inflammation

Motivation: Transcranial low-level near-infrared (NIR) light therapy (LLLT) has been emerging as a therapeutic intervention for traumatic brain injury (TBI).

Goal(s): The goal of this study was to assess the metabolic responses to the administration of LLLT in patients with moderate TBI.

Approach: We used serial 2D MR spectroscopic imaging to measure metabolite concentrations in TBI participants who were either treated with LLLT or with sham.

Results: Sham-treated participants showed a significant increase in myo-inositol/N-acetyl aspartate (mI/NAA) in the corpus callosum 3 months post injury indicating lasting inflammation and neuronal injury, while LLLT treated participants’ mI/NAA ratios remained unchanged.

Impact: This longitudinal study suggests a neuroprotective effect of acute administration of LLLT using MRS on individuals with moderate TBI.

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