Abstract #0688

Assessing Glymphatic Dysfunction in Traumatic Brain Injury Patients Using Delayed T1 Mapping

Jiachen Zhuo¹, Li Jiang¹, Eugenio Rocksmith², Prashant Raghavan¹, Rosy Linda Njonkou Tchoquessi¹, Steven Roys¹, Li Pan³, Tobias Kober⁴, Gary T. Schwartzbauer⁵, Lynn M. Grattan², Emerson M. Wickwire⁶, Rao P. Gullapalli¹, Ze Wang¹, and Neeraj Badjatia²

¹Diagnostic Radiology, University of Maryland School of Medicine, Baltimore, MD, United States, ²Neurology, University of Maryland School of Medicine, Baltimore, MD, United States, ³Siemens Medical Solutions USA Inc, Malvern, PA, United States, ⁴Research & Clinical Translation, Magnetic Resonance, Siemens Healthineers, Erlangen, Germany, ⁵Neurosurgery, University of Maryland School of Medicine, Baltimore, MD, United States, ⁶Medicine, University of Maryland School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Traumatic Brain Injury, Traumatic brain injury, Glymphatic imaging

Motivation: Impaired waste clearance through the glymphatic pathway may contribute to neurodegeneration after traumatic brain injury (TBI).

Goal(s): Our goal is to assess glymphatic dysfunction by tracking gadolinium clearance following intravenous injection in TBI patients and correlating it with cognitive impairments.

Approach: We conducted MRI scans on 38 chronic TBI patients, using T1 mapping at immediate and 6-hour post-injection intervals.

Results: Results indicate that slower gadolinium clearance at delayed 6hr time point, seen as higher T1 reduction, correlates with older age and worse cognitive scores. These findings could establish delayed T1 mapping as a marker for glymphatic health.

Impact: Intravenous T1 mapping provides a non-invasive alternative to intrathecal gadolinium injection for glymphatic system assessment. This method may help validate other contrast-free glymphatic markers, facilitating broader clinical research and improving non-invasive neurodegenerative risk assessments in patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.