Abstract #0692

Associations between neurochemistry and quality-of-life symptoms following sports-related concussion in adolescent athletes

Ved Hatolkar^1,2, Katherine Morigaki Breedlove^1,3, Julie Wilson⁴, Mathew Wingerson⁴, Katherine Smulligan⁴, Michael Kawaja², David Howell^4,5, and Alexander Peter Lin^1,3

¹Center for Clinical Spectroscopy, Brigham and Women's Hospital, Boston, MA, United States, ²Department of Biomedical and Molecular Sciences, Queen's University, Kingston, ON, Canada, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Department of Orthopedics, University of Colorado School of Medicine, Aurora, CO, United States, ⁵Sports Medicine Center, Children's Hospital Colorado, Denver, CO, United States

Synopsis

Keywords: Traumatic Brain Injury, Spectroscopy, Concussion

Motivation: Neurochemical mechanisms of physical deficits following sports-related concussion among adolescent athletes are unclear.

Goal(s): To determine if ¹H-MRS reveals biochemical processes associated with self-reported quality-of-life ratings after concussion.

Approach: MRS of the PCG and ACG were conducted within 3 weeks of concussion, alongside self-reported quality-of-life ratings using PROMIS Pediatric Physical Function, Fatigue, and Pain Interference domains.

Results: In the PCG, tNAA, Glx, tCr, and mI were all negatively correlated with Physical Function, while tNAA and Glx were negatively correlated with Fatigue, and Glx and tCr were negatively correlated with Pain Interference. In the ACG, mI and tCho were negatively associated with Physical Function.

Impact: This study examines anterior and posterior cingulate gyri neurochemistry using magnetic resonance spectroscopy in sports-related concussed adolescents, identifying associations with self-reported quality-of-life ratings. These findings improve our understanding of biochemical factors influencing recovery-related quality-of-life after concussion, better protecting athlete health.

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