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Abstract #0709

Revisiting the ALPS index: Structural Bias on the Glymphatic Interpretation as revealed by post-mortem AD brains

Sihui Li1, Ruike Chen1, Zuozhen Cao1, Yihan Ma1, Qinfeng Zhu1, Keqing Zhu1, Yongquan Huang1, Yao Shen1, Yiqi Shen1, Zhiyong Zhao1, Zixuan Lin1, and Dan Wu1
1Zhejiang University, Hangzhou, China

Synopsis

Keywords: DWI/DTI/DKI, Neurofluids

Motivation: Diffusion tensor imaging based on analysis along the perivascular space (DTI-ALPS) has been used to assess glymphatic function. However, the underlying mechanism for ALPS change remains controversial.

Goal(s): To improve understanding of ALPS from the perspective of structural bias.

Approach: We hypothesized that ALPS reveals total water movement including flowing fluid and restricted diffusion in white matter structure. Post-mortem brains where no flow presented were used to examine the structural contribution to the ALPS.

Results: Structural bias of ALPS was related to AD pathology and aging. Correction for the bias on ALPS weakens its correlation with AD-related indicators.

Impact: The study explored ALPS in post-mortem AD brains from the perspective of structural bias. The underlying mechanism of ALPS alternation, whether the structure or physiology matters, should be interpreted cautiously. This study provides post-mortem and in-vivo insights into the problem.

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