Abstract #0714

Neurite Microstructure Characterization in the Mouse Brain Using Relaxation-Diffusion MRI

Baoxing Ren^1,2, Ye Wu³, Quan Tao^2,4, Yanqiu Feng^1,2, and Xinyuan Zhang^1,2

¹School of Biomedical Engineering, Southern Medical University, Guangzhou, China, ²Guangdong Provincial Key Laboratory of Medical Image Processing & Guangdong Province Engineering Laboratory for Medical Imaging and Diagnostic Technology, Southern Medical University, Guangzhou, China, ³School of Computer Science and Technology, Nanjing University of Science and Technology, Nanjing, China, ⁴Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou, China

Synopsis

Keywords: Diffusion Analysis & Visualization, Diffusion Analysis and Visualization, Relaxation-diffusion

Motivation: Relaxation-diffusion MRI (rdMRI) measurements provide novel insights into tissue microstructural characteristics.

Goal(s): This study aims to apply rdMRI to investigate the age-related microstructural changes in the mouse brain.

Approach: We acquired rdMRI data from in vivo mouse brains across five age groups using a 9.4T MRI scanner. Relaxation-regressed diffusion signals were calculated to extract quantitative diffusion metrics.

Results: Quantitative rdMRI parameters revealed significant age-dependent microstructural differences in the cortex (CX), hippocampus (HC), and corpus callosum (CC). Moreover, the rdMRI technique exhibited sensitivity to alterations in tissue microstructure that cannot be observed by standard single-TE dMRI.

Impact: This study demonstrated the feasibility of using rdMRI to observe brain microstructural changes during development, potentially offering diagnostic markers for age-related diseases.

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