Keywords: Structural Connectivity, Validation, fiber orientations, scattered light imaging
Motivation: Mapping brain’s intricate fiber network is a key quest in neuroscience. However, diffusion MRI is expensive, slow, and probes thousands of fibers/voxel, while micron-resolution methods typically do not resolve crossings, probe limited filed-of-view, or need special sample preparations.
Goal(s): To map fibers in brain sections from any sample preparation with micron-resolution.
Approach: We use computational scattered light imaging (ComSLI) with a simple rotating light and camera setup on new or archived brain histology sections.
Results: We generate micron-resolution fiber maps from histology sections of healthy and diseased human and animal brains, prepared with different protocols, providing ground-truth information for diffusion MRI fiber mapping.
Impact: Using scattered light, we generate micrometer maps of brain fiber orientations in animal and human histology sections, and compare to diffusion MRI. This enables time- and cost-effective studies of brain micro-architecture on new and archived sections from any sample preparation.
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