Meeting Banner
Abstract #0720

Estimating blood oxygen saturation through susceptibility sources separation: a new standpoint on quantitative BOLD models

Lucie Chalet1,2, Sébastien Rigollet3,4, Vasile Stupar3,5, Aurélien Delphin3,5, Thomas Coudert3, Benjamin Lemasson3, Emmanuel L. Barbier3, Laura Mechtouff1,6, Timothé Boutelier2, Emmanuelle Canet-Soulas1, and Thomas Christen3
1INSERM U1060 Cardiovascular Diseases, Metabolism, Diabetology and Nutrition Laboratory, Univ. Claude Bernard Lyon1, Lyon, France, 2Olea Medical, La Ciotat, France, 3INSERM U1216 Grenoble Institute of Neuroscience, Univ. Grenoble Alpes, Grenoble, France, 4Image Guided Therapy, Pessac, France, 5INSERM, US17, CNRS, UAR 3552, CHU Grenoble Alpes, IRMaGe, Univ. Grenoble Alpes, Grenoble, France, 6Stroke Department, Hospices Civils de Lyon, Lyon, France

Synopsis

Keywords: Oxygenation, Oxygenation, Quantitative Susceptibility Mapping, Signal Modeling, Stroke, Biomarkers

Motivation: MR methods have been proposed to estimate blood oxygen saturation (SO2) in cerebral tissues by exploiting the magnetic susceptibility difference between oxy and deoxyhemoglobin. These models neglect the contribution of extravascular susceptibility sources leading to inaccurate measurements.

Goal(s): Recent approaches tried to combine quantitative BOLD and QSM methods but the model neglects the impact of the geometrical arrangements of extravascular sources on signal decay.

Approach: Consequently, we propose a new model to unravel signal contributions of both intravascular and extravascular compartments.

Results: When applied to rat data, SO2 measurements were improved in myelin-rich structures and stroke lesions compared to models neglecting extravascular sources.

Impact: Unraveling extravascular and intravascular signal contributions using our new model holds promise for the characterization of tissular magnetic properties and oxygenation which may serve as biomarkers of hypoxia and predictive tools of damage reversibility in clinical ischemic stroke.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords