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Abstract #0727

Noncontrast assessment of blood-brain barrier permeability to water: improved reliability and spatial specificity

Wen Shi1,2, Jie Song1,2, Jiani Wu1,2, Yifan Gou1,2, Zhiyi Hu1,2, Dengrong Jiang2, Zixuan Lin2, and Hanzhang Lu1,2
1Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, United States, 2Department of Radiology & Radiological Science, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Synopsis

Keywords: Perfusion, Perfusion, Blood-brain-barrier

Motivation: Assessment of blood-brain-barrier (BBB) permeability has received intense interest in neurofluid and neurodegeneration studies.

Goal(s): To improve the WEPCAST MRI technique for the measurement of water BBB permeability in a region-specific manner.

Approach: A generalized venous signal (GVS) model was proposed to estimate the BBB permeability in the superior sagittal sinus (SSS) and straight sinus (SS), providing both cortical and subcortical BBB permeability.

Results: BBB permeability estimated from the GVS method has higher inter-subject and inter-session reliability compared to the existing method. Subcortical BBB permeability is feasible using SS WEPCAST MRI based on the GVS model.

Impact: Non-contrast WEPCAST MRI based on the generalized venous signal model can reliably measure blood-brain-barrier permeability to water with spatial specificity, which has great potential in studying neurological diseases and relevant clinical applications.

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Keywords