Keywords: Perfusion, Perfusion, Blood-brain-barrier
Motivation: Assessment of blood-brain-barrier (BBB) permeability has received intense interest in neurofluid and neurodegeneration studies.
Goal(s): To improve the WEPCAST MRI technique for the measurement of water BBB permeability in a region-specific manner.
Approach: A generalized venous signal (GVS) model was proposed to estimate the BBB permeability in the superior sagittal sinus (SSS) and straight sinus (SS), providing both cortical and subcortical BBB permeability.
Results: BBB permeability estimated from the GVS method has higher inter-subject and inter-session reliability compared to the existing method. Subcortical BBB permeability is feasible using SS WEPCAST MRI based on the GVS model.
Impact: Non-contrast WEPCAST MRI based on the generalized venous signal model can reliably measure blood-brain-barrier permeability to water with spatial specificity, which has great potential in studying neurological diseases and relevant clinical applications.
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