Keywords: Blood Vessels, Flow, Arterial Spin Labeling, Phase Contrast, Cerebral Blood Flow, Cerebrovascular Reactivity, Hypoxia, Hypercapnia
Motivation: Substantial variability has been reported in cerebrovascular reactivity (CVR) under hypercapnia and hypoxia, but it is unclear whether such variability stems from individual physiology or methodological considerations.
Goal(s): We aimed to assess agreement of ASL-CVR with phase contrast (PC-CVR) and evaluate regional contributions.
Approach: ASL and PC cerebral blood flow were collected under normal respiration, hypoxia, and hypercapnia. CVR metrics in PC and ASL were compared. Regional and overall CVR were compared.
Results: ASL-CVR was significantly lower than PC-CVR, likely due to labeling efficiency changes. Similar regions in hypoxia and hypercapnia correlated with overall CVR, suggesting that regional differences do not drive variability.
Impact: We show that ASL measures of cerebrovascular reactivity are significantly lower than phase-contrast measures, and atypical CVR values found in ASL may result from changes in labeling efficiency. Hypoxic CVR variability does not seem to be driven by regional differences.
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