Abstract #0731

Whole-cerebrum Arterial Spin Labeling Perfusion at 7T with isotropic 1 mm and sub-millimeter resolution with 3D TFL-pCASL and Stack-of-Spirals

Chenyang Zhao¹, Zidong Yang¹, Fanhua Guo¹, Qinyang Shou¹, Xingfeng Shao¹, Alexander Beckett², Erica Walker², Samantha Ma³, David A Feinberg², and Danny JJ Wang¹

¹Mark & Mary Stevens Neuroimaging and Informatics Institute, University of Southern California, Los Angeles, CA, United States, ²Erwin Hahn 7T MRI Laboratory, Henry H. Wheeler Brain Imaging Center, Helen Wills Neuroscience Institute, Department of Neuroscience, University of California, Berkeley, Berkeley, CA, United States, ³Siemens Medical Solutions USA, Los Angeles, CA, United States

Synopsis

Keywords: Arterial Spin Labelling, Perfusion

Motivation: Leveraging the benefits of 7T MRI, high-resolution Arterial Spin Labeling perfusion imaging has the potential to provide fine-grained evaluation of brain structure and function.

Goal(s): We aim to achieve isotropic 1 mm and sub-millimeter resolution perfusion imaging with whole-cerebrum coverage.

Approach: We developed a novel 3D TFL-pCASL sequence with Stack-of-Spirals readout, incorporating compressed sensing and advanced correction methods for spiral-related artifacts, such as GIRF and MFI.

Results: high-quality perfusion images comparable to structural scans, with reduced ringing artifacts, enhanced sharpness, and minimized motion sensitivity, were demonstrated, validating the sequence's potential for ultra-high-resolution whole-brain ASL imaging at 7T.

Impact: This study presents high-resolution ASL perfusion imaging at 7T, providing fine-grained assessments of brain structure and function with comparable resolutions and details of structural MRI.

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