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Abstract #0733

Quiet ASL with Non-rephasing Labeling Gradients and Silent Readout

Enjie Zheng1, Jichang Zhang2,3, Jiaxin Li1, and Li Zhao1
1College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou, China, 2Faculty of Science and Engineering, University of Nottingham Ningbo China, Ningbo, China, 3XinGaoYi Medical Equipment Co. LTD, Yuyao, China

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling, Pseudo labeling, WASPI, Acoustic Noise

Motivation: ASL has been used in pediatric perfusion imaging and resting-state fMRI studies. However, the recommended pCASL sequences generate acoustic noise because of the maximum slew rate employed in the labeling and acquisition parts.

Goal(s): To develop a pCASL sequence with reduced acoustic noise.

Approach: Paired triangle-shape gradients without rephasing gradients was proposed to provide pseudo continuous arterial labeling and the WASPI readout, instead of GRASE, was optimized for ASL acquisition.

Results: The proposed quiet pCASL sequence reduced acoustic noise by 47% in the labeling part and 96% in the acquisition part while maintaining competitive image quality compared to conventional pCASL.

Impact: The proposed quiet ASL provided a novel approach to label blood. It may improve patients experience and have a great potential in resting state fMRI studies.

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