Abstract #0737

Multi-module ASL MRA sequences for improving visualization of distal small brain vessels

Ziqi Sun¹, Hongwei Li¹, Lixin Liu¹, Yujun Liao^2,3, Jian Wang⁴, Tiansheng Qian^2,3, Lili Wang¹, Yinghua Chu⁵, He Wang^1,6, and Zhensen Chen^1,6

¹Institute of Science and Technology for Brain-Inspired Intelligence, Fudan University, Shanghai, China, ²Department of Neurosurgery, Fudan University Huashan Hospital, Neurosurgical Institute of Fudan University, Shanghai, China, ³Clinical Medical Center of Neurosurgery, Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China, ⁴Department of Neurosurgery, The Affiliated Changzhou Second People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, Changzhou, China, ⁵MR Research Collaboration Team, Siemens Healthineers Ltd., Shanghai, China, ⁶MOE Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence, Fudan University, Shanghai, China

Synopsis

Keywords: Arterial Spin Labelling, Arterial spin labelling

Motivation: Clear visualization of the distal small vessels in brain is important.

Goal(s): To develop and evaluate multi-module ASL (MMASL) MRA sequences that combine velocity selective (VS) ASL prepulses and spatially selective ASL prepulses for enhanced imaging of distal small brain vessels.

Approach: The VS prepulse was made slab-selective (SS) when combined with spatially selective ASL. Simulations and in vivo experiments were performed to compare ASL MRA sequences with prepulses of PCASL, FAIR, VS, SSVS_PCASL, SSVS_FAIR, SSVS_PCASL_FAIR.

Results: Both simulation and in vivo experiment indicates that SSVS-FAIR achieves better visibility of vessels, particularly for distal small vessels.

Impact: The results indicate that combining SSVS and FAIR can improve imaging of distal small brain vessels, with little compromise for imaging of the proximal vessels, therefore has a great clinical potential.

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