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Abstract #0739

High-fidelity infant regional cerebral blood flow map with isotropic 2mm resolution acquired through segmented 3D GRASE pCASL

Minhui Ouyang1,2, Marta Vidorreta3, Manuel Taso4, John A Detre2,5, and Hao Huang1,2
1Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, 2Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States, 3Siemens Healthcare, Madrid, Spain, 4Siemens Healthcare, Philadelphia, PA, United States, 5Department of Neurology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, United States

Synopsis

Keywords: Arterial Spin Labelling, Perfusion, pediatric; infant; cerebral blood flow; neuroscience;

Motivation: The small infant brain sizes necessitate high-fidelity and high-resolution imaging. Infant cerebral blood flow (CBF) maps at isotropic 2mm resolution are not available.

Goal(s): We aimed to develop a high-resolution infant arterial spin-labeled (ASL) MRI protocol for understanding fundamental infant brain physiology in health and disorders.

Approach: We tested and optimized a cutting-edge segmented 3D GRASE pseudo-continuous-ASL (pCASL) sequence for imaging infant brains.

Results: We achieved the infant CBF maps with highest resolution available to date at isotropic 2mm, capturing the finest details of heterogeneous brain perfusion across various structures including smaller structures such as cerebellum and basal ganglia.

Impact: Capitalizing on an advanced segmented 3D GRASE pCASL with background suppression, we acquired the highest-resolution infant CBF maps available at isotropic 2mm, providing unprecedented details of regional CBF variations across whole infant brain structures characterized by small sizes.

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