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Abstract #0752

Ultra-fast High-Resolution Multi-Contrast Qualitative and Quantitative MRI of the Entire Brain in 3 minutes

Beril Alyuz1,2, Shihan Qiu1, Hsu-Lei Lee1, Chang Gao3, Sreekanth Madhusoodhanan4, Nancy Sicotte4, Pascal Sati1,4, Yibin Xie1, and Debiao Li1,2
1Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, United States, 2Department of Bioengineering, UCLA, Los Angeles, CA, United States, 3MR R&D Collaborations, Siemens Medical Solutions, Los Angeles, CA, United States, 4Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA, United States

Synopsis

Keywords: Machine Learning/Artificial Intelligence, Machine Learning/Artificial Intelligence, Multi-contrast MRI, Brain, Image Synthesis, Quantitative Imaging

Motivation: Multi-contrast and quantitative MRI provide valuable diagnostic information for neurological diseases like multiple sclerosis (MS). However, long scan times make it less practical than CT in time- and motion-sensitive settings.

Goal(s): To develop a deep learning framework to synthesize high-resolution multi-contrast MR images and T1&T2 maps of the brain from a rapid acquisition protocol.

Approach: We used a U-Net-based supervised learning model, taking rapidly acquired low-resolution images and one high resolution image as input and using high-resolution images as the reference.

Results: The framework achieves high-resolution images and quantitative maps with high accuracy, verified by statistical analysis on volunteer and MS patient data.

Impact: The proposed approach enables high-resolution multi-contrast MRI and quantitative mapping of the entire brain in 3 minutes. It can improve and facilitate diagnosis and monitoring of neurological diseases like MS by making detailed brain imaging feasible in time-sensitive clinical settings.

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Keywords