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Abstract #0762

Influence of Diffusion Time and Gradient Strength on the Estimation of Cell Size in MRI Cytometry

Shekhar Adhikari1, Chaoyang Jin1, Jingping Xie1, Jian Wang2, Yuankai Huo3, John Gore1, Xiaoyu Jiang1, and Junzhong Xu1
1Vanderbilt University Institute of Imaging Science, Nashville, TN, United States, 2Department of Radiation Oncology, Vanderbilt University Medical Center, Nashville, TN, United States, 3Department of Electrical Engineering and Computer Science, Vanderbilt University, Nashville, TN, United States

Synopsis

Keywords: Microstructure, Microstructure

Motivation: To investigate the influence of diffusion time and gradient strength on the estimation of cell size in tumors in MRI cytometry.

Goal(s): To find optimal diffusion time range and gradient strength to estimate tumor cell size.

Approach: Two animal tumor models (B16 and MC38) were used. Cell size (d) was estimated utilizing VERDICT, IMPULSED and OGSE only methods at maximum gradient strengths. MRI-derived cell size was compared with histology ground truth.

Results: VERDICT overestimated cell size compared to IMPULSED and OGSE only methods at gradient strength 65mT/m. Accuracy of cell size estimation increases with gradient strength but should cover broad diffusion time range.

Impact: OGSE only and IMPULSED derived mean cell size were comparable at all gradient strengths while VERDICT overestimated the mean cell size at 65mT/m suggesting to include OGSE in estimating tumor cell size.

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Keywords