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Abstract #0769

Tailored Parameter Optimization Framework for Time-dependent Diffusion MRI: Feasibility in Multi-Region Body Imaging at 5.0T

Zhiyuan Zhang1, Lili Wang1, Weirui Cai1, Hongwei Li1, Jiayu Zhu2, Xijing Zhang2, Jianmin Yuan2, He Wang1, and Hao Li1
1The Institute of Science and Technology for Brain-inspired Intelligence, Fudan University, Shanghai, China, 2Central Research Institute, United Imaging Healthcare Group, Shanghai, China

Synopsis

Keywords: Microstructure, Quantitative Imaging

Motivation: Time-dependent diffusion MRI (td-dMRI) offers valuable microstructural insights but faces clinical challenges due to sensitivity to acquisition parameters and system variability.

Goal(s): This study aims to develop an optimization framework for OGSE and PGSE parameters tailored to specific MRI systems and anatomical regions, enhancing the stability and accuracy of quantitative estimations across different SNR levels.

Approach: This framework uses a genetic algorithm to optimize OGSE and PGSE parameters with system performance and tissue-specific SNR constraints, validated on a 5.0T MRI system.

Results: Optimized parameters achieved lower estimation errors and higher stability compared to values typically derived from conventional literature.

Impact: This framework supports broader clinical adoption of td-dMRI by enhancing diagnostic reliability, enabling multi-center standardization, and extending the approach’s applicability to other diffusion imaging models.

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