Abstract #0775

Liver Tumor Differentiation Enhanced by Adding Hepatobiliary Phase MR Fingerprinting: A Multi-parametric Diagnostic Approach

Katsuhiro Sano¹, Shohei Fujita^1,2, Gastao Cruz^3,4, Carlos Velasco³, Diego Pedraza⁵, Hideo Kawasaki¹, Yuki Fukumura⁶, Akiyoshi Suzuki¹, Yutaka Ikenouchi¹, Takashi Arai¹, Yuichi Morita^1,2, Wataru Uchida^1,7, Akio Saiura⁸, Kenichi Ikejima⁹, Koji Kamagata¹, Ryohei Kuwatsuru¹, Rene Botnar^3,5, Claudia Prieto^3,5, and Shigeki Aoki¹⁰

¹Radiology, Juntendo University, Tokyo, Japan, ²Radiology, The University of Tokyo, Tokyo, Japan, ³Department of Biomedical Engineering, School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom, ⁴Radiology, University of Michigan, Ann Arbor, MI, United States, ⁵Institute for Biological and Medical Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, ⁶Human Pathology, Juntendo University, Tokyo, Japan, ⁷Department of Health Data Science, Faculty of Health Data Science, Juntendo University, Chiba, Japan, ⁸Hepatobiliary-Pancreatic Surgery, Juntendo University, Tokyo, Japan, ⁹Gastroenterology, Juntendo University, Tokyo, Japan, ¹⁰Faculty of Health Data Science, Juntendo University, Chiba, Japan

Synopsis

Keywords: Liver, MR Fingerprinting, Liver tumor

Motivation: Liver tumor differentiation by MRI has largely relied on T1 mapping with limited studies incorporating multiple quantitative parameters such as T2. Expanding MR Fingerprinting (MRF) to a multi-parametric approach may improve diagnostic accuracy.

Goal(s): To evaluate the effectiveness of adding MRF during the hepatobiliary phase of gadoxetic acid-enhanced MRI for improved liver tumor differentiation using a multi-parametric approach.

Approach: A 9-echo MRF sequence measured T1, T2, T2*, and FF pre-contrast and MRF-derived T1 reduction rate post-contrast.

Results: MRF-derived T1 reduction rate addition significantly improved benign/malignant differentiation, achieving a multivariate AUC of 0.89.

Impact: Incorporating a multi-parametric approach with MRF during the hepatobiliary phase of gadoxetic acid-enhanced MRI improves diagnostic accuracy in liver tumor differentiation, potentially reducing reliance on dynamic phases and enhancing non-invasive diagnostic capabilities in clinical liver assessments.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.