Meeting Banner
Abstract #0779

Implementation of gadolinium saving potential utilizing Gadopiclenol in vasculitis imaging

Thorsten Alexander Bley1, Ramin Dazeh1, Marc Schmalzing2, Michael Gernert2, Konstanze Guggenberger1, and Viktor Hartung1
1Diagnostic and Interventional Radiology, University Medical Center Wuerzburg, Wuerzburg, Germany, 2Rheumatology, University Medical Center Wuerzburg, Wuerzburg, Germany

Synopsis

Keywords: Vascular/Vessel Wall, Blood vessels, Contrast agents, vasculitis

Motivation: The newly developed contrast agent Gadopiclenol promises high contrast and substantial gadolinium saving potential which shall be realized in vasculitis vessel wall imaging.

Goal(s): To compare objective image quality of 0.05 mmol/kg Gadopiclenol with 0.1 mmol/kg standard dose Gadoteric acid in high resolution scalp arteries and aorta vessel wall imaging in vasculitis.

Approach: Normalized signal intensity and image quality of 3T MRI of 70 patients with suspected giant cell arteritis (25 Gadopiclenol, 45 Gadoteric acid) was compared.

Results: No significant differences of signal intensity of MRA (p>0.87) nor at post-contrast T1weighted SE images (p>0.37) were found between Gadopiclenol and Gadoteric acid scans.

Impact: Gadolinium usage could now be reliably reduced by half utilizing half dose Gadopiclenol while maintaining clinically needed high contrast in vasculitis imaging and aortic imaging, a previously unmet need by other contrast agents.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords