Abstract #0784

Accurate Iron Quantification in Acute Hemorrhagic MI: Alleviating Water Content Sensitivity in Myocardial Edema with Cardiac QSM

Yuheng Huang^1,2, Xin Liu³, xingmin Guan¹, Xinheng Zhang^1,4, Archana Malagi⁵, Gregory Anthony¹, Chia-chi Yang⁵, Li-Ting Huang⁵, Xinqi Li⁵, Ghazal Yoosefian¹, Xiaoming Bi⁶, Debiao Li⁵, Qi Yang³, Hsin-Jung Yang⁵, and Rohan Dharmakumar¹

¹krannert cardiovascular research center, Indiana University School of Medicine, Indianapolis, IN, United States, ²Bioengineering, UCLA, LA, CA, United States, ³Beijing Chaoyang Hospiotal, Capital Medical University, Beijing, China, ⁴Biomedical Imaging Research Institute, Cedars Sinai Medical Center, LA, CA, United States, ⁵Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, LA, CA, United States, ⁶Siemens Healthineers, LA, LA, United States

Synopsis

Keywords: Myocardium, Quantitative Imaging, Quantitative Susceptibility Mapping (QSM); Intramyocardial Hemorrhage; Iron Imaging

Motivation: Hemorrhagic myocardial infarction (hMI) increases the risk of adverse cardiovascular outcomes. Accurate quantification of iron within hMI is critical for improving diagnosis and therapy.

Goal(s): However, the coexistence of iron and edema makes reliable iron quantification challenging. A new motion-robust cardiac HDR-QSM technique has been developed to quantify iron in hMI while reducing confounders associated with conventional R2* (1/T2*) methods.

Approach: This study investigated the difference between HDR-QSM and R2* in acute and chronic hMI and the influence of myocardial edema on accurate iron quantification.

Results: We demonstrated that confounder-corrected cardiac QSM enhances iron sensitivity while reducing edema’s confounding impact on hMI.

Impact: Cardiac QSM can quantify iron content within hMI, with greater sensitivity and accuracy in the presence of myocardial edema than R2* MRI. HDR-QSM may support reliable iron measurement in studies testing therapies against iron's adverse post-hMI effects.

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