Abstract #0792

Tissue remodeling after ischemic stroke influences brain biomechanics and can be captured with MR Elastography

Rebecca Zierold¹, Roland Zerelles¹, Pinar Kilic², Maria Harlacher², Nadine Heselmaier², Tanja Poth³, Axel Barbier⁴, Manuel Fischer¹, Giacomo Annio^4,5, Sara Amin¹, Volker Sturm¹, Sabine Heiland¹, Martin Bendszus¹, Ralph Sinkus^4,6, Hugo Marti², Reiner Kunze², and Katharina Schregel¹

¹Neuroradiology, University Hospital Heidelberg, Heidelberg, Germany, ²Institute for Physiology and Pathophysiology, Medical Faculty Heidelberg, Heidelberg, Germany, ³Center for Model System and Comparative Pathology, University Hospital Heidelberg, Heidelberg, Germany, ⁴Laboratory of Vascular Translation Science, LVTS, U1148, INSERM, Paris, France, ⁵Department of Physics and Computational Radiology, Oslo University Hospital, Oslo, Norway, ⁶School of Biomedical Engineering and Imaging Sciences, King’s College London, London, United Kingdom

Synopsis

Keywords: Elastography, Elastography, brain stiffness; microstructure; ischemia; tissue remodeling

Motivation: Tissue regeneration and reorganization following ischemic stroke are of clinical interest, but are not fully assessable with routinely used imaging techniques.

Goal(s): Determine if post-ischemic brain tissue changes alter brain biomechanics rendering the quantifiable with MR Elastography.

Approach: The MCAO stroke model in C57BL/6 mice was used to longitudinally measure biomechanical properties of infarcted and healthy brain tissue. Imaging metrics were compared to histopathology.

Results: Tissue stiffness and phase angle dynamically changed. This was presumably caused by combined kinetics of tissue degradation and reorganization.

Impact: MR Elastography reveals dynamic biomechanical changes of infarcted and normal appearing brain tissue following transient ischemia. Thus, MRE can support the characterization of post-ischemic tissue reorganization, providing information occult to clinically established imaging techniques.

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