Abstract #0800

Revealing Invisible Prostate Cancer with VERDICT-MRI

Marta Masramon¹, Manju Mathew², Joey Clemente², Adam Retter², Natasha Thorley², Baris Kanber¹, Eoin Dineen³, Greg Shaw^3,4,5, Veeru Kasivisvanathan³, Martyn Carter⁶, Aiman Haider⁷, Alex Freeman⁷, David Atkinson², Daniel C. Alexander¹, Shonit Punwani², and Eleftheria Panagiotaki¹

¹Hawkes Institute, University College London, London, United Kingdom, ²Centre for Medical Imaging, University College London, London, United Kingdom, ³Division of Surgery and Interventional Sciences, University College London, London, United Kingdom, ⁴Department of Urology, UCLH, London, United Kingdom, ⁵Department of Urology, Barts Health NHS Foundation Trust, London, United Kingdom, ⁶Faculty of the Built Environment, University College London, London, United Kingdom, ⁷Department of Pathology, UCLH, London, United Kingdom

Synopsis

Keywords: Prostate, Prostate, Cancer Diffusion VERDICT Invisible

Motivation: Prostate multi-parametric (mp)MRI misses 10-20% of PCa, presenting a need for enhanced imaging techniques.

Goal(s): To determine if VERDICT-MRI, when used alongside mpMRI, can improve the detection and characterization of mpMRI-invisible lesions.

Approach: We identify patients with mpMRI-invisible lesions from the Histo-MRI clinical trial (n=11). We use slice-to-slice matched whole-slide histology and MRI. We analyze differences in histological cell density, epithelial fraction and VERDICT intracellular volume fraction between mpMRI-visible and -invisible lesions.

Results: Using VERDICT-MRI improves the sensitivity of detection of invisible lesions, particularly with high cell density and epithelial fraction.

Impact: Integrating VERDICT-MRI into clinical imaging could enhance detection of previously invisible prostate cancer lesions, allowing for more precise stratification and more informed, personalized treatment strategies, potentially improving patient outcomes.

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