Abstract #0804

The Imaging Findings of an Abbreviated Biparametric MRI Protocol for Prostate Cancer Screening

Natasha Thorley^1,2, Emma Stallard¹, Giorgio Brembilla^1,3,4, Mark Emberton⁵, Caroline M Moore^5,6, and Shonit Punwani^1,2

¹Centre for Medical Imaging, University College London, London, United Kingdom, ²Department of Radiology, University College London Hospital NHS Foundation Trust, London, United Kingdom, ³Clinical and Experimental Radiology Unit, IRCCS San Raffaele Scientific Institute, Milan, Italy, ⁴Vita-Salute San Raffaele University, Milan, Italy, ⁵Division of Surgical and Interventional Science, University College London, London, United Kingdom, ⁶Urology, University College London Hospital NHS Foundation Trust, London, United Kingdom

Synopsis

Keywords: Prostate, MR Value

Motivation: Prostate cancer (PCa) screening via prostate-specific antigen (PSA) testing is prone to over- and under-diagnosis. MRI shows promise but is hindered by long scan times, cost and limited availability.

Goal(s): To evaluate the imaging findings of an abbreviated biparametric (bp)MRI protocol for PCa screening.

Approach: The ReIMAGINE study screened men aged 50-75 with PSA testing and an abbreviated MRI. Positive MRI or raised PSA density ≥0.12 ng/mL² (PSAd) triggered follow-up with multiparametric MRI +/- biopsy.

Results: One in six men had a positive screening MRI. The screening MRI detected more clinically significant cancers than PSAd alone, with a positive predictive value of 59%.

Impact: Prostate MRI may have value in prostate cancer screening independently of prostate-specific antigen testing, offering an opportunity for early cancer detection. Future research is needed to optimise the screening approach to make MRI a more feasible, cost-effective screening tool.

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