Keywords: Prostate, Diffusion Analysis and Visualization, Metrology
Motivation: Diffusion weighted MRI (DWI) has potential as a quantitative imaging biomarker in oncology, but apparent diffusion coefficient (ADC) measurements vary across time, scanners, and protocols.
Goal(s): Demonstrate feasibility of SI traceable in-vivo ADC calibration using reference standards embedded in the scanner couch.
Approach: Nine subjects who had previously undergone clinical mpMRI for suspected prostate cancer underwent repeat DWI scans with a co-patient phantom containing reference diffusivity vials. Calibration functions were constructed to correct bias and calculate uncertainty.
Results: Calibration functions were close to unity. Calibrated ADC maps and uncertainty were generated. Calibration slightly reduced variability in repeat scans.
Impact: This work demonstrates the first in-vivo SI traceable ADC calibration, enabling bias correction and uncertainty quantification on a voxel-wise basis. This is a key step towards establishing ADC as a reliable quantitative imaging biomarker for multicenter oncology studies.
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