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Abstract #0808

A device and method for in-vivo calibration of ADC measurements in prostate cancer

Frank Bolton1, Alistair Lamb2, Natasha Thorley2, Thomas Hampshire1, Shonit Punwani2, David Atkinson2, Xavier Golay1,3, and Aaron Oliver-Taylor1
1Gold Standard Phantoms Limited, Sheffield, United Kingdom, 2Centre for Medical Imaging, University College London, London, United Kingdom, 3Queen Square Institute of Neurology, University College London, London, United Kingdom

Synopsis

Keywords: Prostate, Diffusion Analysis and Visualization, Metrology

Motivation: Diffusion weighted MRI (DWI) has potential as a quantitative imaging biomarker in oncology, but apparent diffusion coefficient (ADC) measurements vary across time, scanners, and protocols.

Goal(s): Demonstrate feasibility of SI traceable in-vivo ADC calibration using reference standards embedded in the scanner couch.

Approach: Nine subjects who had previously undergone clinical mpMRI for suspected prostate cancer underwent repeat DWI scans with a co-patient phantom containing reference diffusivity vials. Calibration functions were constructed to correct bias and calculate uncertainty.

Results: Calibration functions were close to unity. Calibrated ADC maps and uncertainty were generated. Calibration slightly reduced variability in repeat scans.

Impact: This work demonstrates the first in-vivo SI traceable ADC calibration, enabling bias correction and uncertainty quantification on a voxel-wise basis. This is a key step towards establishing ADC as a reliable quantitative imaging biomarker for multicenter oncology studies.

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