Abstract #0812

MIMOSA: Multi-parametric Imaging using Multiple-echoes with Optimized Simultaneous Acquisition for highly-efficient quantitative MRI

Yuting Chen^1,2,3, Yohan Jun^2,3, Amir Heydari⁴, Xingwang Yong^2,3, Huafeng Liu¹, Huihui Ye⁵, Borjan Gagoski^3,6, Berkin Bilgic^2,3,7, and Shohei Fujita^2,3

¹State Key Laboratory of Extreme Photonics and Instrumentation, College of Optical Science and Engineering, Zhejiang University, Hangzhou, China, ²Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Boston, MA, United States, ³Department of Radiology, Harvard Medical School, Boston, MA, United States, ⁴Industrial Engineering and Management Systems, Amirkabir University of Technology, Tehran, Iran (Islamic Republic of), ⁵School of Communication Engineering, Hangzhou Dianzi University, Hangzhou, China, ⁶Fetal-Neonatal Neuroimaging & Developmental Science Center, Boston Children’s Hospital, Boston, MA, United States, ⁷Harvard/MIT Health Sciences and Technology, Massachusetts Institute of Technology, Boston, MA, United States

Synopsis

Keywords: Quantitative Imaging, Quantitative Imaging, Multi-parametric Mapping

Motivation: Fast and highly-efficient simultaneous multi-parametric mapping including para- and dia-magnetic susceptibility mapping can provide detailed insights into tissue composition.

Goal(s): To develop a technique for fast and highly-efficient simultaneous T1, T2, T2*, PD mapping, and source separation QSM.

Approach: MIMOSA was developed based on the 3D-QALAS sequence with complementary variable-density sampling, multi-echo acquisition, and joint multi-contrast reconstruction to enable highly-efficient quantitative mapping.

Results: The accuracy of MIMOSA was validated against reference methods in phantom and in-vivo. Simultaneous whole-brain T1, T2, T2*, PD, and source separation QSM was achieved with 1mm isotropic resolution in 3min at 3T, and 750μm isotropic in 13min at 7T.

Impact: MIMOSA enables whole-brain T1, T2, T2*, PD, QSM, para- and dia-magnetic susceptibility mapping at 1mm isotropic resolution in 3min at 3T and 750μm in 13min at 7T, achieving susceptibility source separation in a single scan for comprehensive tissue characterization.

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