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Abstract #0817

Efficient 3D whole-heart joint T1/T1ρ-adiabatic/T2 mapping and water-fat imaging at 0.55T

Michael G Crabb1, Dongyue Si1, Simon J Littlewood1, Karl P Kunze1,2, Claudia Prieto1,3,4, and Rene M Botnar1,3,4,5,6
1School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, 2MR Research Collaborations, Siemens Healthcare Limited, Camberley, United Kingdom, 3Millenium Institute for Intelligent Healthcare Engineering, Santiago, Chile, 4School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile, 5School of Engineering, Pontificia Universidad Catolica de Chile, Santiago, Chile, 6Institute for Advanced Study, Technical University of Munich, Garching, Germany

Synopsis

Keywords: Pulse Sequence Design, Myocardium, Low-Field MRI

Motivation: 3D whole-heart joint T1/T1ρ/T2 mapping has recently been proposed at 0.55T with continuous wave (CW) T1ρ-preparation. However, the CW T1ρ spin-lock amplitude was relatively small limiting T1ρ dispersion.

Goal(s): To develop a novel free-breathing, 3D joint T1/T1ρ-adiabatic/T2 mapping sequence, with adiabatic T1ρ-preparation to improve dispersion, to provide whole-heart T1, T1ρ-adiabatic, and T2 maps and co-registered water/fat volumes in a ~10 min scan at 0.55T.

Approach: The sequence was tested on phantoms and in-vivo with 4 healthy subjects and 1 patient and compared with conventional 2D mapping references.

Results: Preliminary 3D joint T1/T1ρ-adiabatic/T2 mapping results demonstrate good agreement in phantoms and promising results in-vivo.

Impact: 3D whole-heart T1, T1ρ-adiabatic and T2 maps and co-registered water-fat volumes with isotropic resolution for comprehensive myocardial tissue characterization can be obtained in a single scan of ~10 min at 0.55T.

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Keywords