Keywords: Biomarkers, biomarkers, Myelin
Motivation: Microscopic magnetic field inhomogeneities (µMFIs) carry useful information on tissue microstructure. They have been previously utilised to quantify iron content in-vivo using magnetic field correlation imaging (MFCi), but this technique has never been applied to myelin.
Goal(s): To determine whether MFCi can be used as a quantitative technique for myelin.
Approach: Comparing simulations of myelin-induced µMFIs and ultrahigh-field ex-vivo MFCi in a rodent model of demyelination.
Results: Simulations suggested that demyelination and axonal loss had a measurable effect on MFCi metrics, and ex-vivo imaging showed that MFCi significantly correlated with inhomogenous magnetisation transfer ratio from the same sample.
Impact: Magnetic Field Correlation imaging provides quantitative information on changes to myelin status complementary to other MRI techniques, and offers new ways to characterise microstructural changes in neurodegenerative diseases.
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