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Abstract #0820

Magnetic Field Correlation Imaging Quantifies Demyelination and Axonal Loss

Lewis Kitchingman1, Andreea Hertanu2, Maëliss Jallais1,3, Kadir Şimşek1, Olivier M. Girard4, Guillaume Duhamel4, Lucas Soustelle4, Robert Turner1,5, Emre Kopanoglu1, Ileana Jelescu2, and Marco Palombo1,3
1CUBRIC, Cardiff University, Cardiff, United Kingdom, 2Department of diagnostic and interventional radiology, University of Lausanne, Lausanne, Switzerland, 3School of Computer Science and Informatics, Cardiff University, Cardiff, United Kingdom, 4CNRS, CRMBM, Aix-Merseille University, Merseille, France, 5Department of neurophysics, Max Planck institute for cognitive and brain sciences, Leipzig, Germany

Synopsis

Keywords: Biomarkers, biomarkers, Myelin

Motivation: Microscopic magnetic field inhomogeneities (µMFIs) carry useful information on tissue microstructure. They have been previously utilised to quantify iron content in-vivo using magnetic field correlation imaging (MFCi), but this technique has never been applied to myelin.

Goal(s): To determine whether MFCi can be used as a quantitative technique for myelin.

Approach: Comparing simulations of myelin-induced µMFIs and ultrahigh-field ex-vivo MFCi in a rodent model of demyelination.

Results: Simulations suggested that demyelination and axonal loss had a measurable effect on MFCi metrics, and ex-vivo imaging showed that MFCi significantly correlated with inhomogenous magnetisation transfer ratio from the same sample.

Impact: Magnetic Field Correlation imaging provides quantitative information on changes to myelin status complementary to other MRI techniques, and offers new ways to characterise microstructural changes in neurodegenerative diseases.

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