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Abstract #0826

Quantitative UTE Imaging of the Intervertebral Disc in a Rabbit Spine Disc Puncture Model

Jiyo Srinivasan Athertya1, Arya Suprana1,2, James Lo1,2, Saeed Jerban1, Kiersten Red3, Yujia Ge3, Madeline Brown3, Koichi Masuda3, and Yajun Ma1
1Department of Radiology, UCSD, San Diego, CA, United States, 2Department of Bioengineering, UCSD, San Diego, CA, United States, 3Department of Orthopedic Surgery, UCSD, San Diego, CA, United States

Synopsis

Keywords: Large Animals, Nonhuman Primates, biomarkers, UTE imaging, spine, intervertebral disc

Motivation: Intervertebral disc degeneration is a leading cause of disability, driven by changes in the biochemical components of the disc.

Goal(s): This study aims to investigate the compositional changes associated with disc degeneration using quantitative UTE imaging in punctured rabbit spinal discs.

Approach: Quantitative UTE measurements of T1, MTR, adiabT1rho, and T2 were performed to assess changes in water and proteoglycan content in punctured rabbit spinal discs.

Results: Significant changes in all UTE imaging biomarkers were observed between control and punctured discs, demonstrating the high sensitivity of UTE techniques in detecting compositional alterations in disc associated with degeneration.

Impact: The proposed quantitative UTE imaging techniques enable comprehensive assessment of the IVD degeneration and may improve understanding of the mechanism of low back pain.

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Keywords