Keywords: Large Animals, Nonhuman Primates, biomarkers, UTE imaging, spine, intervertebral disc
Motivation: Intervertebral disc degeneration is a leading cause of disability, driven by changes in the biochemical components of the disc.
Goal(s): This study aims to investigate the compositional changes associated with disc degeneration using quantitative UTE imaging in punctured rabbit spinal discs.
Approach: Quantitative UTE measurements of T1, MTR, adiabT1rho, and T2 were performed to assess changes in water and proteoglycan content in punctured rabbit spinal discs.
Results: Significant changes in all UTE imaging biomarkers were observed between control and punctured discs, demonstrating the high sensitivity of UTE techniques in detecting compositional alterations in disc associated with degeneration.
Impact: The proposed quantitative UTE imaging techniques enable comprehensive assessment of the IVD degeneration and may improve understanding of the mechanism of low back pain.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Keywords