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Abstract #0833

Application of zero-echo time imaging for whole brain activity mapping without signal loss in mice.

Ayako Imamura1,2,3, Rikita Araki4, Yukari Takahashi3, Koichi Miyatake2, Fusao Kato3, Sakiko Honjoh2, and Tomokazu Tsurugizawa3,5,6
1Ph. D. Program in Humanics, University of Tsukuba, Tsukuba, Japan, 2International Institute for Integrative Sleep Medicine (WPI-IIIS), Tsukuba, Japan, 3Department of Neuroscience, The Jikei University School of Medicine, Tokyo, Japan, 4Bruker Japan K.K., Tokyo, Japan, 5Human Informatics and Interaction Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Japan, 6Faculty of Engineering, University of Tsukuba, Tsukuba, Japan

Synopsis

Keywords: Biology, Models, Methods, biology, models, methods

Motivation: Commonly-used T2*-weighted fMRI lacks signals in rodent forebrain regions, including the amygdala, which are crucial for understanding nociceptive responses.

Goal(s): This study aims to evaluate the potential of zero-echo time (ZTE) fMRI to capture activation in the whole brain, especially the amygdala, following pain stimuli.

Approach: ZTE fMRI was used to examine whole-brain responses to formalin-induced hind paw stimulation in rodents, assessing changes in both acute and latent responses.

Results: ZTE successfully imaged brain-wide activation, revealing acute and latent responses in amygdala subregions, supporting its application for comprehensive fMRI studies in mice.

Impact: This study demonstrates ZTE fMRI’s capacity to image activation in the amygdala, even during pain responses, enabling previously challenging investigations into nociception-related networks. This breakthrough opens new avenues for studying pain pathways and emotion regulation, with potential translational relevance.

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Keywords