Keywords: Biology, Models, Methods, biology, models, methods
Motivation: Commonly-used T2*-weighted fMRI lacks signals in rodent forebrain regions, including the amygdala, which are crucial for understanding nociceptive responses.
Goal(s): This study aims to evaluate the potential of zero-echo time (ZTE) fMRI to capture activation in the whole brain, especially the amygdala, following pain stimuli.
Approach: ZTE fMRI was used to examine whole-brain responses to formalin-induced hind paw stimulation in rodents, assessing changes in both acute and latent responses.
Results: ZTE successfully imaged brain-wide activation, revealing acute and latent responses in amygdala subregions, supporting its application for comprehensive fMRI studies in mice.
Impact: This study demonstrates ZTE fMRI’s capacity to image activation in the amygdala, even during pain responses, enabling previously challenging investigations into nociception-related networks. This breakthrough opens new avenues for studying pain pathways and emotion regulation, with potential translational relevance.
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