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Abstract #0841

Preclinical ¹H MRS at Ultra-High Field: A Comparative Study of LASER and STEAM Sequences in Mouse Brain

Alireza Abaei1, Dinesh K Deelchand 2, Francesco Roselli3, and Volker Rasche1
1Core Facility Small Animal Imaging (CF-SANI), Ulm University, Ulm, Germany, 2Center for Magnetic Resonance Research, University of Minnesota, Minneapolis, MN, United States, 3German Center for Neurodegenerative Diseases (DZNE), Ulm University, Ulm, Germany

Synopsis

Keywords: Biology, Models, Methods, Spectroscopy, "Magnetic Resonance Spectroscopy" "Neurochemical Profiling" "Cerebral Metabolism"

Motivation: At ultra-high magnetic fields (UHF), shortened T₂ relaxation times of water and metabolites necessitate efficient magnetic resonance spectroscopy (MRS) sequences like STEAM and LASER.

Goal(s): To compare the neurochemical profiles obtained using LASER and STEAM sequences in the mouse brain at 11.7 T.

Approach: Short echo-time LASER (TE = 16.75 ms) and STEAM (TE/TM = 2.7/10 ms) MRS data were acquired from the caudate-putamen region in nine adult female C57BL/6 mice.

Results: Neurochemical profiles from both sequences were highly correlated (r = 0.97), with LASER showing a twofold increase in SNR compared to STEAM.

Impact: LASER's higher SNR can reduce scan time in preclinical studies at UHF, enabling more efficient data acquisition and facilitating advanced applications like dynamic MRS and neurochemical profiling of smaller brain structures.

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