Abstract #0844

Common coordinate frameworks of developmental marmoset brain from birth to adolescence based on ultra-high-resolution diffusion MRI

Tianjia Zhu^1,2, Ziqin Zhang^1,2, Jianlin Guo^1,3, Minhui Ouyang^1,4, Andre Sousa⁵, Jon Levine⁵, Arnold Kriegstein⁶, and Hao Huang^1,4

¹Department of Radiology, Children's Hospital of Philadelphia, Philadelphia, PA, United States, ²Department of Bioengineering, University of Pennsylvania, Philadelphia, PA, United States, ³Department of Radiology, Beijing Children's Hospital, Beijing, China, ⁴Department of Radiology, University of Pennsylvania, Philadelphia, PA, United States, ⁵Department of Neuroscience, University of Wisconsin-Madison, Madison, WI, United States, ⁶Department of Neurology, University of California San Francisco, San Francisco, CA, United States

Synopsis

Keywords: Large Animals, Nonhuman Primates, Normal development, large animals nonhuman primates, ultra-high-resolution diffusion MRI, common coordinate framework

Motivation: A standardized anatomical common coordinate framework (CCF) is essential to integrate spatially resolved, molecularly defined cell atlases with neurophysiology and behavior for developmental marmoset brain. Ultra-high-resolution diffusion-MRI (dMRI) improves anatomical determinations and provides rich contrasts and microstructural information.

Goal(s): To build the first dMRI-based anatomical CCFs for marmoset brains from birth to adolescence.

Approach: Ultra-high resolution dMRI at 9.4T was performed on neonate, 10-month-old, and 2-year-old marmoset brains. Anatomical regions were delineated.

Results: Ultra-high-resolution CCFs for developmental marmoset brains at isotropic 0.1mm diffusion MRI imaging resolution, characterized by comprehensive labels of fine neuroanatomical structures.

Impact: The first developmental marmoset brain CCFs from birth to adolescence will allow integrating spatially resolved and molecularly defined cell atlas with studies of developing brain function, neurophysiology, and behavior. They will provide insights into evolution and human-specific features of brain development relevant to brain disorders.

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