Abstract #0848

GABA and glutamate changes over time in children with migraine

Tiffany K Bell^1,2,3, Lydia Y Cho^1,2,3, Jonathan Kuziek⁴, Kayla Millar^2,3, Mehak Stokoe^1,2,3, Andrew D Hershey^5,6, Serena L Orr^2,3,4,7,8, and Ashley D Harris^1,2,3

¹Department of Radiology, University of Calgary, Calgary, AB, Canada, ²Hotchkiss Brain Institute, University of Calgary, Calgary, AB, Canada, ³Alberta Children's Hospital Research Institute, University of Calgary, Calgary, AB, Canada, ⁴Department of Pediatrics, University of Calgary, Calgary, AB, Canada, ⁵Division of Neurology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, United States, ⁶Department of Pediatrics, University of Cincinnati, Cincinnati, OH, United States, ⁷Department of Community Health Sciences, University of Calgary, Calgary, AB, Canada, ⁸Department of Clinical Neurosciences, University of Calgary, Calgary, AB, Canada

Synopsis

Keywords: Neuro, Neurotransmission, Migraine

Motivation: Adolescence is a transitory time for migraine in youth. However, there is a lack of research into interactions between brain chemistry changes and migraine progression across adolescence.

Goal(s): Assess the relationship between changes in glutamate and GABA, and migraine burden during adolescence.

Approach: Magnetic resonance spectroscopy (MRS) was used to measure glutamate and GABA levels in youth with and without migraine across two timepoints (on average, 3 years apart).

Results: A decrease in thalamic GABA levels over time was related to new onset migraine in previously unaffected adolescents and worsening of migraine impact in those who already had migraine.

Impact: This longitudinal study demonstrates a role for changes in thalamic GABA levels over time in migraine burden in adolescents, providing new evidence for a role of GABA in migraine onset and progression, and a potential opportunity for new treatment targets.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.