Abstract #0850

Ultra-high field quantitative susceptibility mapping of the neonatal brain

Chiara Casella^1,2,3, Katy Vecchiato^1,2,3, Ayse Sila Dokumaci^3,4, Philippa Bridgen^3,5, Pierluigi Di Ciò^3,5, Ines Tomazinho^2,5, Cidalia Da Costa^2,5, Dario Gallo^2,5, Jucha Willers Moore^2,3, Joseph V Hajnal^3,4, David Edwards^2,5, Jan Sedlacik^3,6, Karin Shmueli^3,7, Tom Wilkinson^3,4, Raphael Tomi-Tricot^3,4,8, David W Carmichael^3,4, Jonathan O’Muircheartaigh^1,2,3,9, Shaihan Malik^3,4, and Tomoki Arichi^2,3,4,5,9

¹Department for Forensic and Neurodevelopmental Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom, ²Early life imaging research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ³London Collaborative Ultra high field System (LoCUS), King's College London, London, United Kingdom, ⁴Imaging physics and engineering research department, School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom, ⁵Guys and St Thomas’ NHS Foundation Trust, King's College London, London, United Kingdom, ⁶Institute of Clinical Sciences, Imperial College, London, United Kingdom, ⁷Department of Medical Physics and Biomedical Engineering, University College London, London, United Kingdom, ⁸MR Research Collaborations, Siemens Healthcare Limited, London, United Kingdom, ⁹MRC Centre for Neurodevelopmental Disorders, King's College London, London, United Kingdom

Synopsis

Keywords: Neuro, Electromagnetic Tissue Properties

Motivation: Brain iron is critical for neurodevelopment, but its quantification in early life is challenging.

Goal(s): To assess the feasibility and sensitivity of 7T QSM for measuring brain iron in the early postnatal period.

Approach: We scanned 12 neonates and 11 children using 7T QSM. We compared susceptibility values in subcortical and cortical regions between neonates and children and assessed associations of susceptibility with gestational age and post-menstrual age in neonates.

Results: We demonstrate the feasibility of 7T QSM in the neonatal brain and show that it can detect regional variations in tissue iron through different stages of brain development.

Impact: 7T QSM is feasible and sensitive to iron deposition in the neonatal brain, offering potential for early detection of iron-related developmental markers. This approach may improve understanding of prematurity’s effects on brain iron and future neurodevelopment.

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