Abstract #0855

Microstructural geometric alterations in autism: relation with brain network and adaptive function

Miaoyan Wang¹, Hua Zhu², Dandan Xu¹, Bo Peng³, Yakang Dai³, Jian Cheng⁴, and Haoxiang Jiang¹

¹Department of Radiology, Affiliated Children's Hospital of Jiangnan University, Wuxi, China, ²Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing, China, ³Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China, ⁴State Key Laboratory of Complex & Critical Software Environment (CCSE), Beihang University, Beijing, China

Synopsis

Keywords: Neuro, Pediatric, Neuro; geometric microstructure

Motivation: It remains unclear whether microstructural geometric alterations exist in the white matter of children with autism spectrum disorder (ASD).

Goal(s): This study investigates microstructural geometric changes in children with ASD, their links to brain network and cognitive function.

Approach: A new mathematical framework, known as Director Field Analysis (DFA), was utilized to examine the orientation characteristics of white matter fibers.

Results: Children with ASD exhibited significantly reduced DFA metrics, which were associated with an increased average clustering coefficient and impaired adaptive function.

Impact: White matter microstructural geometry may provide new insights into the neurobiological mechanisms underlying ASD in children, and serve as biomarkers for the prediction of ASD and adaptive function.

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