Keywords: Neonatal, Ischemia
Motivation: Multi-pool chemical exchange saturation transfer (CEST) MRI provides a comprehensive explanation of neonatal hypoxic-ischemic encephalopathy (HIE) metabolism
Goal(s): Identify brain regions affected by HIE in neonates using multi-pool CEST MRI.
Approach: Study of ten full-term HIE neonates and 25 controls. CEST images were registered to standard space and segmented into six regions using a neonatal atlas.
Results: Significant reductions in NOE, MT, and APT signals were observed in left caudate; MT signal had highest AUC of 0.796.
Impact: Multi-pool Lorentzian fitting method offers detailed metabolic information, potentially serving as an indicator for HIE diagnosis, monitoring, and prognosis.
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