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Abstract #0861

Altered Cortico-Cerebellar Effective Connectivity of the Visuo-Attention System is associated with READ1 deletion in Developmental Dyslexia

Gökçe Korkmaz1,2, Roberta Maria Lorenzi1, Valentina Lampis1,3, Denis Peruzzo4, Filippo Arrigoni5, Doris Pischedda1, Egidio D’Angelo1,6, Fulvia Palesi1, Sara Mascheretti1,3, and Claudia A.M. Gandini Wheeler-Kingshott1,2,6
1Department of Brain and Behavioral Sciences, University of Pavia, Pavia, Italy, 2NMR Research Unit, Queen Square MS Centre, Department of Neuroinflammation, UCL Queen Square Institute of Neurology, Faculty of Brain Sciences, University College London, London, United Kingdom, 3Child Psychopathology Unit, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy, 4Neuroimaging Lab, Scientific Institute, IRCCS Eugenio Medea, Bosisio Parini, Italy, 5Pediatric Radiology and Neuroradiology Department, Children’s Hospital V. Buzzi, Milan, Italy, 6Digital Neuroscience Centre, IRCCS Mondino Foundation, Pavia, Italy

Synopsis

Keywords: Neuro, Genetics, Dynamic Causal Modelling, Effective Connectivity, Cerebellum

Motivation: Aberrant brain functional activation was observed in developmental dyslexia (DD). However, how genetic vulnerability and reading proficiency impact on specific cortico-cerebellar interactions remains unknown.

Goal(s): We investigated how visuo-attentional processing is associated with reading proficiency and genetic vulnerability in DD to understand task-dependent differences in brain connectivity.

Approach: Dynamic Causal Modelling with Parametric Empirical Bayes links individuals' neuronal connection strength to their behavioural measures to characterise aberrant network structures.

Results: Children with DD showed distinctive causal connectivity patterns between the cerebellum and visuo-attentional regions. Particularly, the combination of DD and genetic vulnerability showed remarkable differences in excitation-inhibition dynamics.

Impact: Our approach of combining imaging with genetics demonstrates that effective connectivity between cortico-cerebellar regions involved in attention is essential for reading ability and that genetic alterations impact on the excitatory strength of such connections, providing possible targets for neuro-modulatory interventions.

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Keywords