Keywords: Neuro, Genetics, Dynamic Causal Modelling, Effective Connectivity, Cerebellum
Motivation: Aberrant brain functional activation was observed in developmental dyslexia (DD). However, how genetic vulnerability and reading proficiency impact on specific cortico-cerebellar interactions remains unknown.
Goal(s): We investigated how visuo-attentional processing is associated with reading proficiency and genetic vulnerability in DD to understand task-dependent differences in brain connectivity.
Approach: Dynamic Causal Modelling with Parametric Empirical Bayes links individuals' neuronal connection strength to their behavioural measures to characterise aberrant network structures.
Results: Children with DD showed distinctive causal connectivity patterns between the cerebellum and visuo-attentional regions. Particularly, the combination of DD and genetic vulnerability showed remarkable differences in excitation-inhibition dynamics.
Impact: Our approach of combining imaging with genetics demonstrates that effective connectivity between cortico-cerebellar regions involved in attention is essential for reading ability and that genetic alterations impact on the excitatory strength of such connections, providing possible targets for neuro-modulatory interventions.
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