Abstract #0880

Perfusion and Time of Exchange Measurements in IDH Mutational Subgroups of Gliomas Using BBB-ASL

Gülce Turhan¹, Ayşe İrem Çetin¹, Beatriz Esteves Padrela², Amnah Mahroo³, Simon Konstandin³, Daniel Christopher Hoinkiss³, Nora Josefin Breutigam³, Vera Keil², Ayça Ersen Danyeli^4,5, Koray Özduman^4,6, Klaus Eickel^3,7, Henk Jan Mutsaerts^2,8,9, Matthias Günther^3,10,11, Jan Petr¹², Alp Dinçer^4,13,14, and Esin Ozturk-Isik^1,4

¹Institute of Biomedical Engineering, Bogazici University, İstanbul, Turkey, ²Amsterdam University Medical Center, Amsterdam, Netherlands, ³Fraunhofer Institute for Digital Medicine MEVIS, Bremen, Germany, ⁴Brain Tumor Research Group, Acibadem University, İstanbul, Turkey, ⁵Department Of Pathology, Acibadem University, İstanbul, Turkey, ⁶Department Of Neurosurgery, Acibadem University, İstanbul, Turkey, ⁷Bremerhaven University of applied Sciences, Bremerhaven, Germany, ⁸Brain Imaging, Amsterdam Neuroscience, Amsterdam, Netherlands, ⁹Radiology and Nuclear Medicine, Vrije Universiteit, Amsterdam, Netherlands, ¹⁰mediri GmbH, Heidelberg, Germany, ¹¹University of Bremen, Bremen, Germany, ¹²Helmholtz-Zentrum Dresden-Rossendorf, Dresden, Germany, ¹³Department of Radiology, Acibadem University, İstanbul, Turkey, ¹⁴Neuroradigical Applications and Research Center, Acibadem University, İstanbul, Turkey

Synopsis

Keywords: Data Processing, Arterial spin labelling

Motivation: Unlike contrast-enhanced T1-weighted MRI, which may overlook subtle blood-brain barrier (BBB) integrity changes, the blood-brain barrier arterial spin labeling (BBB-ASL) technique offers a novel non-invasive method to assess BBB disruptions.

Goal(s): To analyze the cerebral blood flow (CBF) and exchange time (Tex) differences between the isocitrate dehydrogenase (IDH) mutational subgroups of gliomas using BBB-ASL.

Approach: Tex and CBF maps of 25 gliomas were estimated using a region-specific T2-correction within the BBB-ASL model and were compared using a Mann-Whitney U test.

Results: IDH-wildtype tumors had significantly higher perfusion than IDH-mutant tumors. Although exchange times were lower in IDH-wildtype tumors, this difference was not significant.

Impact: Our findings underscore the promising potential of multi-echo BBB-ASL in evaluating BBB integrity and identifying IDH mutational subgroups of gliomas.

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