Abstract #0883

Feasibility of Time-Dependent Diffusion MRI-Based Indicators for Identifying MGMT Promoter Methylation in High-Grade Gliomas

Qingjun Wang¹, Yan Xie¹, Yun Zhang², Xiaojing Liang¹, Yonggui Fu¹, Chen Zhang³, Feiweier Thorsten⁴, and Meining Chen³

¹Radiology, The 6th Medical Center, Chinese PLA General Hospital, Beijing, China, Beijing, China, ²Radiology, The Peking University International Hospital, Beijing, China., Beijing, China, ³MR Research Collaboration, The Siemens Healthineers, Beijing, China., Beijing, China, ⁴Department of MR Research and Clinical Translation, The Siemens Healthineers AG, Erlangen, Germany., Erlangen, Germany

Synopsis

Keywords: Tumors (Pre-Treatment), biomarkers, time-diffusion MRI; microstructure; oscillating gradient spin-echo; glioma; MGMT methylation

Motivation: High-grade gliomas (HGGs) require accurate diagnosis of O⁶-methylguanine-DNA methyltransferase (MGMT) promoter methylation status, which requires invasive biopsies. Therefore, non-invasive diagnostic alternatives are needed.

Goal(s): We aimed to assess the feasibility of using time-dependent diffusion MRI to differentiate between methylated and unmethylated MGMT promoters in HGGs.

Approach: We used pulsed and oscillating gradient sequences in diffusion MRI to measure microstructural indicators, such as intracellular volume fraction and cellularity, in patients with HGGs.

Results: Time-dependent diffusion MRI revealed significant differences between HGGs with methylated vs unmethylated MGMT, providing a highly accurate diagnostic model based on intracellular volume fraction and cellularity.

Impact: Our findings may help enabling non-invasive diagnostics for patients with HGGs by providing reliable prognostic tools and may inspire further research into MRI-based techniques for characterizing tumors as well as help guide clinical decision-making for patients unsuitable for biopsy.

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