Meeting Banner
Abstract #0887

First demonstration of resting-state functional MRI on a 1.5T MR-Linac to assess functional connectivity in glioblastoma patients

Eaman Almasri 1,2, Liam Lawrence1,2, James Stewart3, Mark Ruschin3, Aimee Theriault3, Jay Detsky3, Sten Myrehaug3, Chia-Lin (Eric) Tseng3, Hany Soliman3, Arjun Sahgal3, and Angus Lau1,2
1Medical Biophysics, University of Toronto, Toronto, ON, Canada, 2Physical Sciences, Sunnybrook Health Sciences Centre, Toronto, ON, Canada, 3Department of Radiation Oncology, Sunnybrook Health Sciences Centre, University of Toronto, Toronto, ON, Canada

Synopsis

Keywords: Tumors (Post-Treatment), fMRI (resting state), Functional Connectivity, Glioblastoma, MR-Linac

Motivation: Glioblastomas are infiltrative brain tumors linked to neuro-cognitive impairments. Monitoring functional connectivity with MRI-linear accelerator (MR-Linac) during radiotherapy could guide treatment adaptation. However, the feasibility of monitoring changes in resting-state functional MRI (rs-fMRI) on MR-Linacs has yet to be validated.

Goal(s): We sought to determine the repeatability of rs-fMRI on a 1.5T MR-Linac during radiotherapy in glioblastoma patients.

Approach: We acquired weekly rs-fMRI in 25 glioblastoma patients during radiotherapy and evaluated the repeatability of functional connectivity across sessions.

Results: We provided the first demonstration of MR-Linac rs-fMRI. Functional connectivity patterns were patient-specific, with high within-patient repeatability.

Impact: We showed that frequent resting-state functional imaging on MRI-linear accelerators is feasible, with high within-patient and low across-patient session similarity. These findings suggest a potential for tracking individual functional network changes during radiotherapy to guide treatment adaptation in glioblastoma patients.

How to access this content:

For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.

After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.

After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.

Click here for more information on becoming a member.

Keywords