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Abstract #0899

In vivo diffusion-weighted imaging on a point-of-care 46mT Halbach MRI scanner

Chloe Najac1, Yiming Dong1, Beatrice Lena1, Ruben van den Broek1, Peter Börnert1,2, and Andrew Webb1
1C.J. Gorter MRI Center, Radiology, Leiden University Medical Center, Leiden, Netherlands, 2Philips Research Hamburg, Hamburg, Germany

Synopsis

Keywords: Low-Field MRI, Low-Field MRI

Motivation: Low-field MRIs for point-of-care (POC) applications are emerging, especially for low- and middle-income countries and intensive care and emergency units. Diffusion-weighted imaging (DWI) is crucial for clinical practice, requiring robust DWI protocols on POC scanners.

Goal(s): Our goal was to implement a robust DWI sequence on our 46mT Halbach-based POC scanner.

Approach: Due to B0 inhomogeneities and gradient constraints, we opted for a 3D turbo-spin echo sequence with a DW spin echo pre-module. We tested the sequence using a quantitative phantom and in vivo.

Results: We obtained clean diffusion maps in phantom and in vivo, although diffusion coefficients are currently still slightly overestimated.

Impact: We implemented a DWI sequence on a 46mT MRI and acquired data in healthy brains. We evaluated the feasibility of acquiring under-sampled data to fasten acquisition and to use b-values similar to the ones used in clinical practice.

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