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Abstract #0906

Repeatability of rapid T1 mapping of brain tissues at 64 mT: a multicenter study

Beatrice Lena1, Francesco Padormo2, Rui Pedro A.G. Teixeira2, Carly Bennallick3, James Gholam4, Ruben van den Broek1, Samson Lecurieux Lafayette5, Irene M. Vavasour6, Niall Bourke3, Todor Karaulanov7, Mara Cercignani4, Derek K Jones4, Shannon Kolind6, Jo Hajnal5, Sean Deoni8, Steven C.R. Williams3, Andrew Webb1, Pia C Sundgren9,10, and Emil Ljungberg3,11
1Leids Universitair Medisch Centrum, Leiden, Netherlands, 2Hyperfine Inc., Guilford, CT, United States, 3Department of Neuroimaging, King's College London, London, United Kingdom, 4CUBRIC, Cardiff School of Psychology, Cardiff University, Cardiff, United Kingdom, 5Perinatal Imaging & Health, King’s College London, London, United Kingdom, 6University of British Columbia, Vancouver, BC, Canada, 7CaliberMRI, Boulder, CO, United States, 8MNCH D&T, Bill & Melinda Gates Foundation, Seattle, WA, United States, 9Institution of Clinical Sciences/Radiology, Lund University, Lund, Sweden, 10Lund Bioimaging Centre, Lund, Sweden, 11Department of Medical Radiation Physics, Lund University, Lund, Sweden

Synopsis

Keywords: Low-Field MRI, White Matter, Gray Matter, Multisite, Repeatability

Motivation: Low-field MRI has the potential to improve healthcare worldwide. T1 mapping, a biomarker for brain pathology and development, lacks a rapid and repeatable protocol at low field MRI.

Goal(s): Develop and validate a clinically feasible, reproducible T1 mapping protocol at 64 mT, achieving stable measurements across multiple sites.

Approach: We implemented a 10-minute T1 mapping protocol on identical low-field MRI systems at six sites, acquiring in vivo (N=60) and phantom data to assess repeatability.

Results: The protocol achieved high reproducibility, with inter-site variations below ±3% in phantom, providing repeatable non significantly different T1 values in white and grey matter in N=60 volunteers.

Impact: Our multi-site study establishes repeatable T1 mapping in vivo and in phantom at 64 mT in a 10-minute protocol, offering robust, quantitative brain tissue characterization suitable for clinical applications in Point-of-Care settings.

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