Keywords: Lung, Lung
Motivation: Regional variations in pulmonary ventilation and perfusion profoundly impacts respiratory function; understanding their distribution and underlying mechanisms is critical for improving therapeutic interventions and patient outcomes.
Goal(s): To investigate the redistribution of regional lung function between different postures in both the apex-to-base and anterior-to-posterior directions.
Approach: Participants were investigated sagittally using an Open 0.5T MRI in three postures: sitting, supine and prone to vary the relative direction of gravity experienced by the lungs.
Results: Results showed significant redistribution of lung function between each of the three postures, both in the apical-to-basal and anterior-to-posterior directions.
Impact: A deeper understanding of lung function variability in response to postural changes will enhance clinical decision-making in pulmonary medicine. Additionally, posture dependent lung function could serve as a marker for lung disease and support stratified treatment approaches.
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