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Abstract #0912

Lung Ventilation-Perfusion Imaging Approaches in the Single Ventricle Heart

Eamon K Doyle1, Ecrin Yagiz2, Sophia Cui3, Jon Detterich4, Roberta Kato4, and Krishna Nayak2
1Radiology, Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA, United States, 2University of Southern California, Los Angeles, CA, United States, 3Siemens Medical Solutions, Millbourne, PA, United States, 4Children's Hospital of Los Angeles, University of Southern California, Los Angeles, CA, United States

Synopsis

Keywords: Lung, Low-Field MRI

Motivation: Techniques have been developed to conduct non-invasive lung ventilation and perfusion imaging with MRI. In single ventricle patients, their pulmonary blood flow is non-pulsatile, so it is unknown if these techniques will work in this patient population.

Goal(s): To investigate whether new ventilation/perfusion techniques work in absence of pulsatile lung blood flow seen in single ventricle subjects.

Approach: We imaged human subjects with normal and single ventricle hearts and post-processed the data through two ventilation-perfusion pipelines to assess feasibility.

Results: The normal subjects demonstrate similar ventilation and perfusion patterns in both pipelines. Single ventricle subjects demonstrate similar ventilation maps but differing perfusion maps.

Impact: These results will help to determine which imaging approaches work best for patients with single ventricle heart defects, which will provide functional information for research and clinical use.

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