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Abstract #0915

129Xe multi-b Diffusion Weighted Imaging of lung with 3D Golden-Angle Radial Sampling and Keyhole Reconstruction

Luyang Shen1, Haidong Li1,2, Yuan Fang1, Qian Zhou1, Ming Zhang1,2, Xiuchao Zhao1,2, Lei Shi1,2, Yeqing Han1,2, and Xin Zhou1,2
1State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences-Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan, China, 2University of Chinese Academy of Sciences, Beijing, China

Synopsis

Keywords: Lung, Hyperpolarized MR (Gas)

Motivation: Conventional 129Xe GRE DWI requires long acquisition time and has large slice thickness, limiting its applications in patients with pulmonary diseases.

Goal(s): To develop a method to accelerate 129Xe multi-b DWI and obtain isotropic DW images, enabling assessment of morphology changes caused by lung diseases.

Approach: We combined 3D golden-angle radial sampling with keyhole reconstruction (GRSK) to conduct pulmonary 129Xe DWI, and applied it in patients with emphysema.

Results: By using the proposed method, 4 b-values pulmonary DW images with a spatial resolution of 5×5×5 mm3 could be acquired within 11.4 s.

Impact: 3D GRSK method was used to accelerate multi-b 129Xe DWI, obtaining 4 b-values pulmonary DW images with isotropic resolution of 5 mm within 11.4 s, and was applied in patients with emphysema.

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