Abstract #0917

Dependence of diffusion and ventilation metrics on hyperpolarized 129Xe lung MRI with demographics in healthy volunteers

Guilhem J. Collier^1,2, Alberto M. Biancardi^1,2, Ho-Fung Chan¹, Helen Marshall^1,2, Laurie J. Smith¹, Laura Saunders^1,2, Neil J. Stewart^1,2, Graham Norquay¹, Paul J.C. Hughes¹, and Jim M. Wild^1,2

¹Division of Clinical Medicine, School of Medicine & Population Health, University of Sheffield, Sheffield, United Kingdom, ²INSIGNEO institute, University of Sheffield, Sheffield, United Kingdom

Synopsis

Keywords: Lung, Aging

Motivation: The normal ranges of pulmonary ¹²⁹Xe diffusion and ventilation MRI metrics are not well established.

Goal(s): To evaluate the influence of age, sex, height, and weight on ¹²⁹Xe-MRI diffusion and ventilation metrics in a cohort of healthy volunteers.

Approach: 3D diffusion-weighted SPGR and 3D SSFP ventilation images were acquired in 65 and 42 healthy volunteers, respectively.

Results: Over the age range of 9 to 70 years, mean diffusion coefficients and alveolar dimensions were strongly correlated with age (Spearman r=0.73, p < 0.0001). The ventilation defect percentage was not correlated with any demographics, but some markers of ventilation heterogeneity increase significantly with age.

Impact: Defining normal ranges for diffusion and ventilation ¹²⁹Xe MRI metrics is important for clinical interpretation. Results show a significant increase of alveolar dimensions with age and provide an upper limit of normal for the ventilation defect percentage metric.

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