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Abstract #0974

Microstructure and muscle strength in older adults: a time-dependent diffusion study

Valentina Mazzoli1, Smita Rao2, Dannyelle Long2, Soniya Sharad Kadam2, Gregory Lemberskiy3, Thorsten Feiweier4, Gregor Koerzdoerfer 5, Dmitry S Novikov1, Els Fieremans1, and Santiago Coelho1
1Radiology, NYU Langone, New York, NY, United States, 2NYU, New York, NY, United States, 3MICSI, New York, NY, United States, 4Siemens Healthineers AG, Erlangen, Germany, 5MR R&D Collaborations, Siemens Medical Solutions USA, Malvern, PA, United States

Synopsis

Keywords: Muscle, Aging, rpbm

Motivation: Treatments exist to help prevent the development of sarcopenia and muscle atrophy in older adults, but the detection of early signs of atrophy is challenging. DTI can detect features of muscle atrophy associated with decrease force production, but it has low specificity.

Goal(s): Our goal was to determine if time-dependent diffusion with RPBM modeling can increase the specificity to muscle fiber atrophy.

Approach: Data collected from older adults at multiple mixing times were fit with RPBM and the apparent diameter a was determined.

Results: RPBM-derived a has better performance at describing microstructural features related to force production, compared to conventional DTI.

Impact: The apparent diameter a, obtained by modeling time-dependent diffusion data combined with RPBM modeling, is strongly associated to muscle strength in older adults, and is therefore a promising tool to study early signs of muscle atrophy and sarcopenia.

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