Keywords: Muscle, Muscle, exercise, perfusion
Motivation: Quantification of the blood flow response to exercise provides insight into skeletal muscle health.
Goal(s): To define the repeatability and sensitivity of perfusion changes in activated skeletal muscle in response to in-scanner isometric plantarflexion contraction in healthy individuals.
Approach: vPIVOT MRI was used to measure perfusion throughout either two 70% maximum or a series of 30%, 50%, and 70% maximum isometric plantarflexion contractions. Intra-session repeatability and sensitivity of perfusion time course metrics to varied doses of exercise intensity were evaluated.
Results: The area and timing to half recovery were both repeatable and sensitive to exercise-induced changes in activated muscles.
Impact: Dynamic measurement of skeletal muscle perfusion in response to in-scanner exercise with vPIVOT MRI was repeatable and sensitive to varied exercise intensity in healthy adults. These results will help to facilitate comparison in future studies of patient populations.
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