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Abstract #0986

Long-term monitoring bone porosity in vivo T1DM Rabbits using UTE-MRI

kejun wang1, Weiyin Vivian Liu2, Haoran Lei1, Renjie Yang1, and Yunfei Zha1
1Department of Radiology, Renmin Hospital of Wuhan University, wuhan, China, 2MR Research, GE Healthcare, beijing, China

Synopsis

Keywords: Bone/Skeletal, Diabetes, Bone, UTE-MRI

Motivation: Given the high fracture risk associated with Type 1 diabetes, especially in cortical bone-rich regions, precise assessment beyond bone mineral density (BMD) is essential.

Goal(s): This study aims to investigate the feasibility of the porosity index (PI) derived from ultrashort echo time MRI (UTE-MRI) to assess cortical bone porosity and geometry changes.

Approach: Using a T1DM rabbit model, we applied UTE-MRI to monitor cortical bone porosity over time, validated against micro-computed tomography (micro-CT), histology, and quantitative PCR (qPCR) in both diabetic and control groups.

Results: Increased PI in diabetic rabbits was correlated with impaired bone remodeling processes, compared to control rabbits.

Impact: UTE-MRI is feasible to assess cortical bone porosity and geometry in T1DM, offering a non-invasive, radiation-free method to evaluate bone health. This technique supports fracture evaluation and management guideline in diabetic patients, improving clinical outcomes.

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